# The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial

> **NCT00430989** · PHASE4 · COMPLETED · sponsor: **Bayside Health** · enrollment: 7112 (actual)

## Conditions studied

- Coronary Artery Disease

## Interventions

- **OTHER:** Nitrous Oxide
- **OTHER:** No Nitrous Oxide

## Key facts

- **NCT ID:** NCT00430989
- **Lead sponsor:** Bayside Health
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-04
- **Primary completion:** 2013-09
- **Final completion:** 2013-09
- **Target enrollment:** 7112 (ACTUAL)
- **Last updated:** 2026-01-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00430989

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00430989, "The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT00430989. Licensed CC0.

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