# Low-dose Hormone Therapy for Relief of Vasomotor Symptoms

> **NCT00446199** · PHASE3 · COMPLETED · sponsor: **Bayer** · enrollment: 735 (actual)

## Conditions studied

- Vasomotor Symptoms
- Hot Flashes

## Interventions

- **DRUG:** 0.5mg DRSP / 0.5mg E2 (BAY86-4891)
- **DRUG:** 0.25mg DRSP / 0.5mg E2 (BAY86-4891)
- **DRUG:** Estradiol (E2 0.3mg)
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00446199
- **Lead sponsor:** Bayer
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-03
- **Primary completion:** 2008-10
- **Final completion:** 2008-11
- **Target enrollment:** 735 (ACTUAL)
- **Last updated:** 2015-05-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00446199

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00446199, "Low-dose Hormone Therapy for Relief of Vasomotor Symptoms". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00446199. Licensed CC0.

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