# Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence

> **NCT00447564** · PHASE3 · COMPLETED · sponsor: **Titan Pharmaceuticals** · enrollment: 163 (actual)

## Conditions studied

- Opioid Dependence

## Interventions

- **DRUG:** Probuphine
- **DRUG:** placebo

## Key facts

- **NCT ID:** NCT00447564
- **Lead sponsor:** Titan Pharmaceuticals
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-10
- **Primary completion:** 2008-07
- **Final completion:** 2008-07
- **Target enrollment:** 163 (ACTUAL)
- **Last updated:** 2018-12-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00447564

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00447564, "Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00447564. Licensed CC0.

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