# Arsenic Trioxide, Fluorouracil, and Leucovorin in Treating Patients With Stage IV Colorectal Cancer That Has Relapsed or Not Responded to Treatment

> **NCT00449137** · PHASE1 · COMPLETED · sponsor: **University of Miami** · enrollment: 13 (actual)

## Conditions studied

- Colorectal Cancer

## Interventions

- **DRUG:** Arsenic trioxide
- **DRUG:** Fluorouracil
- **DRUG:** Leucovorin calcium
- **OTHER:** Plasma levels of elemental arsenic
- **GENETIC:** Peripheral Blood Mononuclear Cells (PBMC) for mRNA analysis
- **PROCEDURE:** Tumor Biopsy (Fine-Needle Aspiration)

## Key facts

- **NCT ID:** NCT00449137
- **Lead sponsor:** University of Miami
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2005-06
- **Primary completion:** 2010-02
- **Final completion:** 2010-12
- **Target enrollment:** 13 (ACTUAL)
- **Last updated:** 2016-12-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00449137

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00449137, "Arsenic Trioxide, Fluorouracil, and Leucovorin in Treating Patients With Stage IV Colorectal Cancer That Has Relapsed or Not Responded to Treatment". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00449137. Licensed CC0.

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