Donor Peripheral Stem Cell Transplant and Donor Natural Killer Cell Transplant After Total-Body Irradiation, Thiotepa, Fludarabine, and Muromonab-CD3 in Treating Patients With Leukemia or Other Blood Diseases

NCT00450983 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

1

Enrollment

OTHER

Sponsor class

Conditions

Graft Versus Host Disease
Leukemia
Myelodysplastic Syndromes

Interventions

BIOLOGICAL: muromonab-CD3
BIOLOGICAL: natural killer cell therapy
DRUG: fludarabine phosphate
DRUG: methotrexate
DRUG: thiotepa
GENETIC: gene expression analysis
OTHER: flow cytometry
OTHER: immunologic technique
PROCEDURE: allogeneic hematopoietic stem cell transplantation
PROCEDURE: in vitro-treated peripheral blood stem cell transplantation
RADIATION: total-body irradiation

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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