Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes

Conditions

• Leukemia
• Myelodysplastic Syndromes

Interventions

• BIOLOGICAL: alemtuzumab
• DRUG: arsenic trioxide
• DRUG: azacitidine
• DRUG: busulfan
• DRUG: clofarabine
• DRUG: cytarabine
• DRUG: daunorubicin hydrochloride
• DRUG: fludarabine phosphate
• DRUG: gemtuzumab ozogamicin
• DRUG: melphalan
• DRUG: tipifarnib
• GENETIC: DNA methylation analysis
• GENETIC: cytogenetic analysis
• GENETIC: gene expression analysis
• GENETIC: mutation analysis
• OTHER: diagnostic laboratory biomarker analysis
• OTHER: immunologic technique
• PROCEDURE: allogeneic hematopoietic stem cell transplantation
• PROCEDURE: nonmyeloablative allogeneic hematopoietic stem cell transplantation

Sponsor

The University of New South Wales