# A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.

> **NCT00462345** · PHASE4 · COMPLETED · sponsor: **Hoffmann-La Roche** · enrollment: 40 (actual)

## Conditions studied

- Rheumatoid Arthritis

## Interventions

- **DRUG:** rituximab
- **DRUG:** Methotrexate
- **DRUG:** Corticosteroid or NSAID
- **DIETARY_SUPPLEMENT:** Folate

## Key facts

- **NCT ID:** NCT00462345
- **Lead sponsor:** Hoffmann-La Roche
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-06
- **Primary completion:** 2009-07
- **Final completion:** 2009-07
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2014-11-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00462345

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00462345, "A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT00462345. Licensed CC0.

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