# Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)

> **NCT00471809** · PHASE4 · TERMINATED · sponsor: **National Heart, Lung, and Blood Institute (NHLBI)** · enrollment: 210 (—)

## Conditions studied

- Asthma

## Interventions

- **DRUG:** Budesonide + Salmeterol + Azithromycin
- **DRUG:** Budesonide + Salmeterol + Montelukast
- **DRUG:** Budesonide + Salmeterol + Placebo

## Key facts

- **NCT ID:** NCT00471809
- **Lead sponsor:** National Heart, Lung, and Blood Institute (NHLBI)
- **Sponsor class:** NIH
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2006-03
- **Primary completion:** —
- **Final completion:** 2007-03
- **Target enrollment:** 210 (—)
- **Why stopped:** The CARE Network DSMB recommended to the NHLBI that the MARS trial be terminated, based on a futility analysis with 55 randomized children.
- **Last updated:** 2016-07-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00471809

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00471809, "Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)". Retrieved via AI Analytics 2026-07-10 from https://api.ai-analytics.org/clinical/NCT00471809. Licensed CC0.

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