# Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation

> **NCT00487032** · PHASE4 · COMPLETED · sponsor: **Brian J Lipworth** · enrollment: 19 (actual)

## Conditions studied

- Allergic Rhinitis
- Tachyphylaxis
- Rhinitis Medicamentosa

## Interventions

- **DRUG:** Oxymetazoline 0.05% w/v
- **DRUG:** Fluticasone propionate 50 micrograms per actuation
- **DRUG:** Prazosin hydrochloride
- **DRUG:** Placebo to Prazosin

## Key facts

- **NCT ID:** NCT00487032
- **Lead sponsor:** Brian J Lipworth
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2008-05
- **Primary completion:** 2009-05
- **Final completion:** 2009-05
- **Target enrollment:** 19 (ACTUAL)
- **Last updated:** 2019-04-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00487032

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00487032, "Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00487032. Licensed CC0.

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