# Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee

> **NCT00488267** · PHASE3 · COMPLETED · sponsor: **ZARS Pharma Inc.** · enrollment: 679 (actual)

## Conditions studied

- Osteoarthritis

## Interventions

- **DRUG:** ThermoProfen™ (Matrix Transdermal Ketoprofen/CHADD™ System)
- **DRUG:** Placebo Matrix/CHADD Patch
- **DRUG:** Ketoprofen matrix/placebo CHADD Patch

## Key facts

- **NCT ID:** NCT00488267
- **Lead sponsor:** ZARS Pharma Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-06
- **Primary completion:** 2008-06
- **Final completion:** 2008-09
- **Target enrollment:** 679 (ACTUAL)
- **Last updated:** 2012-05-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00488267

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00488267, "Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT00488267. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*