# Decitabine in Treating Patients With Previously Untreated Acute Myeloid Leukemia

> **NCT00492401** · PHASE2 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 55 (actual)

## Conditions studied

- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Adult Acute Myeloid Leukemia With Del(5q)
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- Secondary Acute Myeloid Leukemia
- Untreated Adult Acute Myeloid Leukemia

## Interventions

- **DRUG:** decitabine
- **OTHER:** laboratory biomarker analysis
- **OTHER:** pharmacological study
- **OTHER:** high performance liquid chromatography
- **GENETIC:** microarray analysis
- **GENETIC:** RNA analysis
- **OTHER:** mass spectrometry
- **GENETIC:** DNA methylation analysis
- **OTHER:** matrix-assisted laser desorption/ionization time of flight mass spectrometry

## Key facts

- **NCT ID:** NCT00492401
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-05
- **Primary completion:** 2010-12
- **Final completion:** 2014-10
- **Target enrollment:** 55 (ACTUAL)
- **Last updated:** 2016-06-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00492401

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00492401, "Decitabine in Treating Patients With Previously Untreated Acute Myeloid Leukemia". Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/clinical/NCT00492401. Licensed CC0.

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