# Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx

> **NCT00498953** · PHASE1,PHASE2 · COMPLETED · sponsor: **European Organisation for Research and Treatment of Cancer - EORTC** · enrollment: 7 (actual)

## Conditions studied

- Head and Neck Cancer

## Interventions

- **DRUG:** carboplatin
- **DRUG:** cisplatin
- **DRUG:** docetaxel
- **DRUG:** fluorouracil
- **DRUG:** lapatinib ditosylate
- **GENETIC:** cytogenetic analysis
- **GENETIC:** fluorescence in situ hybridization
- **GENETIC:** in situ hybridization
- **GENETIC:** polymerase chain reaction
- **GENETIC:** reverse transcriptase-polymerase chain reaction
- **OTHER:** immunohistochemistry staining method
- **OTHER:** laboratory biomarker analysis
- **PROCEDURE:** conventional surgery
- **PROCEDURE:** neoadjuvant therapy
- **RADIATION:** fludeoxyglucose F 18
- **RADIATION:** radiation therapy

## Key facts

- **NCT ID:** NCT00498953
- **Lead sponsor:** European Organisation for Research and Treatment of Cancer - EORTC
- **Sponsor class:** NETWORK
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-05
- **Primary completion:** 2008-11
- **Final completion:** 2009-03
- **Target enrollment:** 7 (ACTUAL)
- **Last updated:** 2018-07-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00498953

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00498953, "Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00498953. Licensed CC0.

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