# Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma

> **NCT00499616** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 464 (actual)

## Conditions studied

- Neuroblastoma

## Interventions

- **DRUG:** carboplatin
- **DRUG:** cyclophosphamide
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** etoposide
- **DRUG:** topotecan hydrochloride
- **DRUG:** Isotretinoin
- **PROCEDURE:** Surgery
- **DRUG:** Filgrastim

## Key facts

- **NCT ID:** NCT00499616
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-10-08
- **Primary completion:** 2014-06-30
- **Final completion:** 2021-06-30
- **Target enrollment:** 464 (ACTUAL)
- **Last updated:** 2021-07-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00499616

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00499616, "Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00499616. Licensed CC0.

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