# Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee

> **NCT00504127** · PHASE3 · COMPLETED · sponsor: **NicOx** · enrollment: 1020 (actual)

## Conditions studied

- Osteoarthritis

## Interventions

- **DRUG:** Naproxcinod 375 mg bid
- **DRUG:** Naproxcinod 750 mg bid
- **DRUG:** Naproxen 500 mg bid
- **DRUG:** placebo

## Key facts

- **NCT ID:** NCT00504127
- **Lead sponsor:** NicOx
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-04
- **Primary completion:** 2008-12
- **Final completion:** —
- **Target enrollment:** 1020 (ACTUAL)
- **Last updated:** 2011-06-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00504127

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00504127, "Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00504127. Licensed CC0.

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