# Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

> **NCT00507091** · PHASE1 · COMPLETED · sponsor: **Genzyme, a Sanofi Company** · enrollment: 24 (actual)

## Conditions studied

- Metastatic
- Colorectal
- Adenocarcinoma

## Interventions

- **DRUG:** ZD6474 (vandetanib) 100mg
- **DRUG:** Irinotecan
- **DRUG:** 5-Fluorouracil
- **DRUG:** Leucovorin
- **DRUG:** ZD6474 (vandetanib) 300mg

## Key facts

- **NCT ID:** NCT00507091
- **Lead sponsor:** Genzyme, a Sanofi Company
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2005-08
- **Primary completion:** 2006-05
- **Final completion:** 2008-06
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2016-08-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00507091

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00507091, "Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT00507091. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*