Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant

NCT00513474 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

46

Enrollment

OTHER

Sponsor class

Conditions

Chronic Myeloproliferative Disorders
Graft Versus Host Disease
Leukemia
Lymphoma
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Myelodysplastic/Myeloproliferative Neoplasms

Interventions

DRUG: busulfan
DRUG: cyclophosphamide
DRUG: cyclosporin-A
DRUG: etoposide
DRUG: methotrexate
DRUG: rasburicase
DRUG: sirolimus
DRUG: tacrolimus
PROCEDURE: allogeneic hematopoietic stem cell transplantation
PROCEDURE: peripheral blood stem cell transplantation
RADIATION: total-body irradiation
DRUG: fludarabine
DRUG: allopurinol

Sponsor

Massachusetts General Hospital