# Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma

> **NCT00544778** · PHASE2 · TERMINATED · sponsor: **City of Hope Medical Center** · enrollment: 7 (actual)

## Conditions studied

- Sarcoma

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** dexrazoxane hydrochloride
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** ifosfamide
- **DRUG:** irinotecan hydrochloride
- **GENETIC:** protein expression analysis
- **OTHER:** immunoenzyme technique
- **PROCEDURE:** adjuvant therapy
- **PROCEDURE:** conventional surgery
- **PROCEDURE:** neoadjuvant therapy
- **RADIATION:** radiation therapy

## Key facts

- **NCT ID:** NCT00544778
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2001-08
- **Primary completion:** 2011-11
- **Final completion:** —
- **Target enrollment:** 7 (ACTUAL)
- **Why stopped:** The study was terminated prematurely due to withdrawal of support by the sponsor.
- **Last updated:** 2014-08-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00544778

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00544778, "Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT00544778. Licensed CC0.

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