# Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I

> **NCT00546507** · PHASE3 · COMPLETED · sponsor: **Mika Pharma GmbH** · enrollment: 650 (actual)

## Conditions studied

- Osteoarthritis

## Interventions

- **DRUG:** TDS-943 (topical diclofenac sodium 4% spray)
- **DRUG:** celecoxib
- **OTHER:** placebo

## Key facts

- **NCT ID:** NCT00546507
- **Lead sponsor:** Mika Pharma GmbH
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-10
- **Primary completion:** 2008-10
- **Final completion:** 2008-10
- **Target enrollment:** 650 (ACTUAL)
- **Last updated:** 2010-10-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00546507

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00546507, "Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT00546507. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*