# Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

> **NCT00557193** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 218 (actual)

## Conditions studied

- Acute Lymphoblastic Leukemia
- Acute Undifferentiated Leukemia
- Childhood T Acute Lymphoblastic Leukemia

## Interventions

- **DRUG:** Asparaginase
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Biopsy
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Daunorubicin Hydrochloride
- **DRUG:** Dexamethasone
- **PROCEDURE:** Echocardiography
- **DRUG:** Etoposide
- **BIOLOGICAL:** Filgrastim
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Lestaurtinib
- **DRUG:** Leucovorin Calcium
- **DRUG:** Mercaptopurine
- **DRUG:** Methotrexate
- **DRUG:** Methylprednisolone
- **PROCEDURE:** Multigated Acquisition Scan
- **DRUG:** Pegaspargase
- **OTHER:** Pharmacological Study
- **DRUG:** Prednisone

## Key facts

- **NCT ID:** NCT00557193
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2008-01-15
- **Primary completion:** 2017-09-30
- **Final completion:** 2024-06-30
- **Target enrollment:** 218 (ACTUAL)
- **Last updated:** 2024-07-15

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00557193

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00557193, "Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia". Retrieved via AI Analytics 2026-06-16 from https://api.ai-analytics.org/clinical/NCT00557193. Licensed CC0.

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