# Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma

> **NCT00621452** · PHASE1 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 12 (estimated)

## Conditions studied

- B-cell Chronic Lymphocytic Leukemia
- Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue
- Nodal Marginal Zone B-cell Lymphoma
- Recurrent Grade 1 Follicular Lymphoma
- Recurrent Grade 2 Follicular Lymphoma
- Recurrent Mantle Cell Lymphoma
- Recurrent Marginal Zone Lymphoma
- Recurrent Small Lymphocytic Lymphoma
- Refractory Chronic Lymphocytic Leukemia
- Splenic Marginal Zone Lymphoma
- Waldenström Macroglobulinemia

## Interventions

- **BIOLOGICAL:** therapeutic autologous lymphocytes
- **DRUG:** cyclophosphamide
- **BIOLOGICAL:** aldesleukin
- **GENETIC:** polymerase chain reaction
- **GENETIC:** gene rearrangement analysis
- **PROCEDURE:** lymph node biopsy
- **BIOLOGICAL:** genetically engineered lymphocyte therapy
- **PROCEDURE:** bone marrow aspiration
- **OTHER:** flow cytometry
- **OTHER:** laboratory biomarker analysis
- **OTHER:** enzyme-linked immunosorbent assay

## Key facts

- **NCT ID:** NCT00621452
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-08
- **Primary completion:** 2014-01
- **Final completion:** —
- **Target enrollment:** 12 (ESTIMATED)
- **Last updated:** 2014-08-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00621452

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00621452, "Genetically Engineered Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Indolent B-Cell Non-Hodgkin Lymphoma". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00621452. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*