# Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery

> **NCT00646659** · PHASE2 · TERMINATED · sponsor: **European Organisation for Research and Treatment of Cancer - EORTC** · enrollment: 47 (actual)

## Conditions studied

- Head and Neck Cancer

## Interventions

- **BIOLOGICAL:** cetuximab
- **DRUG:** carboplatin
- **DRUG:** cisplatin
- **DRUG:** docetaxel
- **DRUG:** fluorouracil
- **GENETIC:** fluorescence in situ hybridization
- **GENETIC:** molecular genetic technique
- **GENETIC:** reverse transcriptase-polymerase chain reaction
- **OTHER:** immunoenzyme technique
- **OTHER:** immunohistochemistry staining method
- **OTHER:** laboratory biomarker analysis
- **PROCEDURE:** biopsy
- **RADIATION:** 3-dimensional conformal radiation therapy
- **RADIATION:** intensity-modulated radiation therapy

## Key facts

- **NCT ID:** NCT00646659
- **Lead sponsor:** European Organisation for Research and Treatment of Cancer - EORTC
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2008-02
- **Primary completion:** 2010-05
- **Final completion:** 2011-04
- **Target enrollment:** 47 (ACTUAL)
- **Why stopped:** Recruitment was suspended prematurely for safety concerns and closed after IDMC review
- **Last updated:** 2018-07-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00646659

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00646659, "Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00646659. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*