# To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension

> **NCT00662896** · PHASE1 · COMPLETED · sponsor: **NicOx** · enrollment: 300 (estimated)

## Conditions studied

- Osteoarthritis
- Hypertension

## Interventions

- **DRUG:** naproxcinod 375 mg bid
- **DRUG:** naproxcinod 750 mg bid
- **DRUG:** naproxen 250 mg bid
- **DRUG:** naproxen 500 mg bid
- **DRUG:** ibuprofen 600 mg tid

## Key facts

- **NCT ID:** NCT00662896
- **Lead sponsor:** NicOx
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2008-03
- **Primary completion:** 2008-09
- **Final completion:** 2008-12
- **Target enrollment:** 300 (ESTIMATED)
- **Last updated:** 2011-06-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00662896

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00662896, "To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension". Retrieved via AI Analytics 2026-07-13 from https://api.ai-analytics.org/clinical/NCT00662896. Licensed CC0.

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