# Biomarkers in Women Receiving Chemotherapy & Celecoxib for Stage II or Stage III Breast Cancer Removable by Surgery

> **NCT00665457** · PHASE2 · TERMINATED · sponsor: **University of Nebraska** · enrollment: 3 (actual)

## Conditions studied

- Breast Cancer

## Interventions

- **BIOLOGICAL:** filgrastim
- **DRUG:** capecitabine
- **DRUG:** celecoxib
- **DRUG:** cyclophosphamide
- **DRUG:** docetaxel
- **DRUG:** doxorubicin hydrochloride
- **GENETIC:** gene expression analysis
- **GENETIC:** polymorphism analysis
- **GENETIC:** protein expression analysis
- **GENETIC:** reverse transcriptase-polymerase chain reaction
- **OTHER:** imaging biomarker analysis
- **OTHER:** immunohistochemistry staining method
- **OTHER:** laboratory biomarker analysis
- **OTHER:** pharmacogenomic studies
- **PROCEDURE:** dynamic contrast-enhanced magnetic resonance imaging
- **PROCEDURE:** needle biopsy
- **PROCEDURE:** neoadjuvant therapy
- **PROCEDURE:** radiomammography
- **PROCEDURE:** ultrasound imaging

## Key facts

- **NCT ID:** NCT00665457
- **Lead sponsor:** University of Nebraska
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2004-04-15
- **Primary completion:** 2009-07-31
- **Final completion:** 2009-07-31
- **Target enrollment:** 3 (ACTUAL)
- **Why stopped:** study drug was removed from the market and low enrollment.
- **Last updated:** 2023-09-13

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00665457

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00665457, "Biomarkers in Women Receiving Chemotherapy & Celecoxib for Stage II or Stage III Breast Cancer Removable by Surgery". Retrieved via AI Analytics 2026-07-18 from https://api.ai-analytics.org/clinical/NCT00665457. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*