Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
Conditions
- Acute Lymphoblastic Leukemia
- Adult B Acute Lymphoblastic Leukemia
- Childhood B Acute Lymphoblastic Leukemia
Interventions
- DRUG: Calaspargase Pegol-mknl
- DRUG: Cyclophosphamide
- DRUG: Cytarabine
- DRUG: Daunorubicin Hydrochloride
- DRUG: Dexamethasone
- DRUG: Doxorubicin Hydrochloride
- OTHER: Laboratory Biomarker Analysis
- DRUG: Mercaptopurine
- DRUG: Methotrexate
- DRUG: Pegaspargase
- OTHER: Pharmacological Study
- DRUG: Prednisone
- RADIATION: Radiation Therapy
- DRUG: Thioguanine
- DRUG: Vincristine Sulfate
Sponsor
Children's Oncology Group
Collaborators