# Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease

> **NCT00719888** · PHASE2 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 135 (actual)

## Conditions studied

- Acute Biphenotypic Leukemia
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Burkitt Lymphoma
- Chronic Lymphocytic Leukemia
- Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Follicular Lymphoma
- Lymphoblastic Lymphoma
- Lymphoplasmacytic Lymphoma
- Mantle Cell Lymphoma
- Marginal Zone Lymphoma
- Myelodysplastic Syndrome
- Myelofibrosis
- Non-Hodgkin Lymphoma
- Plasma Cell Myeloma
- Prolymphocytic Leukemia
- Refractory Anemia
- Small Lymphocytic Lymphoma

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Cyclosporine
- **PROCEDURE:** Double-Unit Umbilical Cord Blood Transplantation
- **DRUG:** Fludarabine
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Mycophenolate Mofetil
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Umbilical Cord Blood Transplantation
- **DRUG:** Thiotepa

## Key facts

- **NCT ID:** NCT00719888
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2005-11-18
- **Primary completion:** 2023-12-22
- **Final completion:** 2024-12-19
- **Target enrollment:** 135 (ACTUAL)
- **Last updated:** 2025-03-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00719888

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00719888, "Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00719888. Licensed CC0.

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