# The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients

> **NCT00731003** · NA · COMPLETED · sponsor: **Maastricht University Medical Center** · enrollment: 60 (actual)

## Conditions studied

- Irritable Bowel Syndrome

## Interventions

- **DRUG:** Oxitriptan
- **OTHER:** Acute tryptophan depletion
- **OTHER:** Amino acid drink with tryptophan
- **DRUG:** Placebo capsule

## Key facts

- **NCT ID:** NCT00731003
- **Lead sponsor:** Maastricht University Medical Center
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-04
- **Primary completion:** 2011-05
- **Final completion:** 2011-05
- **Target enrollment:** 60 (ACTUAL)
- **Last updated:** 2014-11-13

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00731003

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00731003, "The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and Irritable Bowel Syndrome (IBS) Patients". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT00731003. Licensed CC0.

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