# Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study

> **NCT00733330** · PHASE4 · TERMINATED · sponsor: **DePuy International** · enrollment: 86 (actual)

## Conditions studied

- Osteoarthritis

## Interventions

- **DEVICE:** Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique
- **DEVICE:** Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation

## Key facts

- **NCT ID:** NCT00733330
- **Lead sponsor:** DePuy International
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2005-01
- **Primary completion:** 2008-12
- **Final completion:** 2010-12
- **Target enrollment:** 86 (ACTUAL)
- **Why stopped:** A sample size recalculation indicated an increase from 154 to 1500 subjects was required so the study stopped as new target was considered unfeasible.
- **Last updated:** 2014-08-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00733330

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00733330, "Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT00733330. Licensed CC0.

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