# Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

> **NCT00742924** · PHASE1 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 24 (actual)

## Conditions studied

- Sarcoma

## Interventions

- **DRUG:** cisplatin
- **DRUG:** dexrazoxane hydrochloride
- **DRUG:** doxorubicin hydrochloride
- **DRUG:** etoposide
- **DRUG:** ifosfamide
- **DRUG:** leucovorin calcium
- **DRUG:** methotrexate
- **DRUG:** zoledronic acid
- **PROCEDURE:** adjuvant therapy
- **PROCEDURE:** neoadjuvant therapy
- **PROCEDURE:** therapeutic conventional surgery
- **BIOLOGICAL:** filgrastim
- **DRUG:** Mesna

## Key facts

- **NCT ID:** NCT00742924
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2008-08
- **Primary completion:** 2012-04
- **Final completion:** —
- **Target enrollment:** 24 (ACTUAL)
- **Last updated:** 2014-07-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00742924

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00742924, "Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00742924. Licensed CC0.

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