Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer
Stopped The trial was stopped early because there was only one patient with pCR among the first 15 patients randomized to the curcumin arm.
Conditions
- Rectal Mucinous Adenocarcinoma
- Rectal Signet Ring Cell Adenocarcinoma
- Recurrent Rectal Carcinoma
- Stage IIA Rectal Cancer AJCC v7
- Stage IIB Rectal Cancer AJCC v7
- Stage IIC Rectal Cancer AJCC v7
- Stage IIIA Rectal Cancer AJCC v7
- Stage IIIB Rectal Cancer AJCC v7
- Stage IIIC Rectal Cancer AJCC v7
Interventions
- DRUG: Capecitabine
- DIETARY_SUPPLEMENT: Curcumin
- OTHER: Laboratory Biomarker Analysis
- OTHER: Pharmacological Study
- OTHER: Placebo
- OTHER: Quality-of-Life Assessment
- RADIATION: Radiation Therapy
Sponsor
M.D. Anderson Cancer Center
Collaborators