# Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer

> **NCT00745134** · PHASE2 · TERMINATED · sponsor: **M.D. Anderson Cancer Center** · enrollment: 22 (actual)

## Conditions studied

- Rectal Mucinous Adenocarcinoma
- Rectal Signet Ring Cell Adenocarcinoma
- Recurrent Rectal Carcinoma
- Stage IIA Rectal Cancer AJCC v7
- Stage IIB Rectal Cancer AJCC v7
- Stage IIC Rectal Cancer AJCC v7
- Stage IIIA Rectal Cancer AJCC v7
- Stage IIIB Rectal Cancer AJCC v7
- Stage IIIC Rectal Cancer AJCC v7

## Interventions

- **DRUG:** Capecitabine
- **DIETARY_SUPPLEMENT:** Curcumin
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study
- **OTHER:** Placebo
- **OTHER:** Quality-of-Life Assessment
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT00745134
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2008-08-11
- **Primary completion:** 2022-11-11
- **Final completion:** 2022-11-11
- **Target enrollment:** 22 (ACTUAL)
- **Why stopped:** The trial was stopped early because there was only one patient with pCR among the first 15 patients randomized to the curcumin arm.
- **Last updated:** 2023-09-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00745134

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00745134, "Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT00745134. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*