# The Pathophysiology of Orthostatic Hypotension

> **NCT00748059** · PHASE1 · COMPLETED · sponsor: **Vanderbilt University Medical Center** · enrollment: 10 (actual)

## Conditions studied

- Autonomic Nervous System Diseases
- Orthostatic Hypotension
- Dopamine Beta-Hydroxylase Deficiency
- Orthostatic Intolerance

## Interventions

- **PROCEDURE:** Standing or upright tilt
- **PROCEDURE:** Microneurography
- **PROCEDURE:** QSweat
- **DEVICE:** neck cuff stimulation
- **DRUG:** phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine
- **DRUG:** clonidine,yohimbine,metoclopramide,alpha-methyldopa
- **PROCEDURE:** BodPod
- **PROCEDURE:** Eye exam
- **PROCEDURE:** Sleep study
- **PROCEDURE:** Pain response testing
- **PROCEDURE:** Metabolic chamber
- **PROCEDURE:** Brain function studies
- **PROCEDURE:** Bicycle Exercise Test

## Key facts

- **NCT ID:** NCT00748059
- **Lead sponsor:** Vanderbilt University Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 1996-12
- **Primary completion:** 2020-12
- **Final completion:** 2020-12
- **Target enrollment:** 10 (ACTUAL)
- **Last updated:** 2021-05-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00748059

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00748059, "The Pathophysiology of Orthostatic Hypotension". Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/clinical/NCT00748059. Licensed CC0.

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