# Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children

> **NCT00749723** · PHASE2,PHASE3 · COMPLETED · sponsor: **University Hospital, Bonn** · enrollment: 174 (actual)

## Conditions studied

- Recurrent Brain Tumors
- Supratentorial PNETs
- Medulloblastomas
- Ependymomas

## Interventions

- **DRUG:** carboplatin
- **DRUG:** etoposide
- **DRUG:** temozolomide
- **DRUG:** thiotepa, carboplatin, etoposide
- **DRUG:** temozolomide, thiotepa
- **PROCEDURE:** autologous stem cell transplantation
- **DRUG:** intraventricular etoposide
- **DRUG:** trofosfamide, etoposide

## Key facts

- **NCT ID:** NCT00749723
- **Lead sponsor:** University Hospital, Bonn
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2006-02-01
- **Primary completion:** 2015-01-31
- **Final completion:** 2016-01-31
- **Target enrollment:** 174 (ACTUAL)
- **Last updated:** 2018-07-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00749723

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00749723, "Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00749723. Licensed CC0.

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