# A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

> **NCT00754572** · PHASE3 · COMPLETED · sponsor: **Hoffmann-La Roche** · enrollment: 418 (actual)

## Conditions studied

- Rheumatoid Arthritis

## Interventions

- **DRUG:** tocilizumab [RoActemra/Actemra]
- **DRUG:** methotrexate

## Key facts

- **NCT ID:** NCT00754572
- **Lead sponsor:** Hoffmann-La Roche
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-02
- **Primary completion:** 2012-10
- **Final completion:** 2012-10
- **Target enrollment:** 418 (ACTUAL)
- **Last updated:** 2015-05-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00754572

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00754572, "A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis". Retrieved via AI Analytics 2026-07-01 from https://api.ai-analytics.org/clinical/NCT00754572. Licensed CC0.

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