# Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study

> **NCT00779324** · NA · COMPLETED · sponsor: **Wake Forest University Health Sciences** · enrollment: 168 (actual)

## Conditions studied

- Brain Injury
- Aggression

## Interventions

- **DRUG:** Amantadine Hydrochloride
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00779324
- **Lead sponsor:** Wake Forest University Health Sciences
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-08
- **Primary completion:** 2013-04
- **Final completion:** 2013-05
- **Target enrollment:** 168 (ACTUAL)
- **Last updated:** 2022-07-12

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00779324

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00779324, "Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00779324. Licensed CC0.

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