# Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment

> **NCT00800150** · PHASE1 · TERMINATED · sponsor: **City of Hope Medical Center** · enrollment: 6 (actual)

## Conditions studied

- Chronic Myeloproliferative Disorders
- Leukemia
- Lymphoma
- Multiple Myeloma and Plasma Cell Neoplasm
- Myelodysplastic Syndromes
- Myelodysplastic/Myeloproliferative Neoplasms

## Interventions

- **DRUG:** fludarabine phosphate
- **DRUG:** melphalan
- **PROCEDURE:** nonmyeloablative allogeneic hematopoietic stem cell transplantation
- **RADIATION:** intensity-modulated radiation therapy
- **RADIATION:** tomotherapy
- **RADIATION:** total marrow irradiation
- **RADIATION:** total nodal irradiation

## Key facts

- **NCT ID:** NCT00800150
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2008-11
- **Primary completion:** 2010-10
- **Final completion:** 2010-10
- **Target enrollment:** 6 (ACTUAL)
- **Why stopped:** Protocol objective could not be met. A new study with amended eligibility criteria will be developed.
- **Last updated:** 2015-06-08

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00800150

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00800150, "Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By Donor Stem Cell Transplant in Treating Patients With Advanced Hematological Cancer That Has Not Responded to Treatment". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT00800150. Licensed CC0.

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