# Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

> **NCT00818389** · PHASE2,PHASE3 · TERMINATED · sponsor: **Massachusetts General Hospital** · enrollment: 84 (actual)

## Conditions studied

- Amyotrophic Lateral Sclerosis

## Interventions

- **DRUG:** Lithium Carbonate
- **DRUG:** Riluzole
- **DRUG:** placebo

## Key facts

- **NCT ID:** NCT00818389
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2009-01
- **Primary completion:** 2009-10
- **Final completion:** 2009-10
- **Target enrollment:** 84 (ACTUAL)
- **Why stopped:** NINDS DSMB recommended trial be terminated for futility after reviewing an interim analysis of 84 subjects.
- **Last updated:** 2011-04-19

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00818389

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00818389, "Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT00818389. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*