# Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)

> **NCT00871871** · PHASE1 · COMPLETED · sponsor: **Merck Sharp & Dohme LLC** · enrollment: 64 (actual)

## Conditions studied

- Hypertension

## Interventions

- **DRUG:** Hydrochlorothiazide (HCTZ)
- **DRUG:** Comparator: Placebo to HCTZ
- **DRUG:** Isosorbide mononitrate (ISMN)
- **DRUG:** Comparator: Placebo to ISMN

## Key facts

- **NCT ID:** NCT00871871
- **Lead sponsor:** Merck Sharp & Dohme LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-03
- **Primary completion:** 2010-02
- **Final completion:** 2010-03
- **Target enrollment:** 64 (ACTUAL)
- **Last updated:** 2015-07-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00871871

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00871871, "Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT00871871. Licensed CC0.

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