# Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy

> **NCT00895245** · PHASE2 · TERMINATED · sponsor: **University of Washington** · enrollment: 6 (actual)

## Conditions studied

- Nausea and Vomiting
- Stage III Squamous Cell Carcinoma of the Hypopharynx
- Stage III Squamous Cell Carcinoma of the Larynx
- Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity
- Stage III Squamous Cell Carcinoma of the Nasopharynx
- Stage III Squamous Cell Carcinoma of the Oropharynx
- Stage IV Squamous Cell Carcinoma of the Hypopharynx
- Stage IV Squamous Cell Carcinoma of the Larynx
- Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity
- Stage IV Squamous Cell Carcinoma of the Nasopharynx
- Stage IV Squamous Cell Carcinoma of the Oropharynx

## Interventions

- **DRUG:** fosaprepitant dimeglumine
- **DRUG:** cisplatin
- **DRUG:** palonosetron hydrochloride
- **DRUG:** dexamethasone
- **OTHER:** Functional Living Index-Emesis Questionnaire
- **BEHAVIORAL:** Emesis Diary
- **RADIATION:** Radiotherapy

## Key facts

- **NCT ID:** NCT00895245
- **Lead sponsor:** University of Washington
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2009-02
- **Primary completion:** 2010-09
- **Final completion:** 2011-02
- **Target enrollment:** 6 (ACTUAL)
- **Why stopped:** Study stopped due to lack of efficacy in first 6 patients
- **Last updated:** 2017-05-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00895245

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00895245, "Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT00895245. Licensed CC0.

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