Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD

NCT00914940 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

41

Enrollment

OTHER

Sponsor class

Stopped Did not reach one of the primary endpoints of decreased total acute GVHD

Conditions

Graft Versus Host Disease
Leukemia
Myelodysplastic Syndromes

Interventions

DRUG: Fludarabine Phosphate
DRUG: Tacrolimus
DRUG: Thiotepa
RADIATION: Total-Body Irradiation (TBI)
OTHER: Magnetic Affinity Cell Sorting
PROCEDURE: Peripheral Blood Stem Cell Transplantation
PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
BIOLOGICAL: T Cell-Depleted Hematopoietic Stem Cell Transplantation

Sponsor

Fred Hutchinson Cancer Center

Collaborators

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