# A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers

> **NCT00973232** · PHASE1 · COMPLETED · sponsor: **Labopharm Inc.** · enrollment: 58 (actual)

## Conditions studied

- Healthy

## Interventions

- **DRUG:** DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl)
- **DRUG:** DDS-06C (650 mg acetaminophen and 75 mg tramadol)
- **DRUG:** Zaldiar®
- **DRUG:** Ultracet®
- **DRUG:** Two tablets of DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), multiple doses, under both fed and fasting conditions
- **DRUG:** Zaldiar®, multiple doses,(fed & fasting):
- **DRUG:** Ultracet®, multiple doses, (fed & fasting)

## Key facts

- **NCT ID:** NCT00973232
- **Lead sponsor:** Labopharm Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2008-05
- **Primary completion:** 2008-08
- **Final completion:** 2008-08
- **Target enrollment:** 58 (ACTUAL)
- **Last updated:** 2012-04-25


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00973232

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00973232, "A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT00973232. Licensed CC0.

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