# Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer

> **NCT00977574** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 349 (actual)

## Conditions studied

- Endometrial Adenocarcinoma
- Endometrial Adenosquamous Carcinoma
- Endometrial Clear Cell Adenocarcinoma
- Endometrial Serous Adenocarcinoma
- Recurrent Malignant Uterine Corpus Neoplasm
- Stage IIIA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
- Stage IIIB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
- Stage IIIC Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
- Stage IVA Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage
- Stage IVB Uterine Corpus Carcinoma or Carcinosarcoma by AJCC v7 Stage

## Interventions

- **BIOLOGICAL:** Bevacizumab
- **DRUG:** Carboplatin
- **DRUG:** Ixabepilone
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Paclitaxel
- **DRUG:** Temsirolimus

## Key facts

- **NCT ID:** NCT00977574
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2009-09-14
- **Primary completion:** 2015-01-31
- **Final completion:** 2027-03-06
- **Target enrollment:** 349 (ACTUAL)
- **Last updated:** 2026-04-29

## Collaborators

- NRG Oncology

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00977574

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00977574, "Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT00977574. Licensed CC0.

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