# Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)

> **NCT00988559** · PHASE1 · COMPLETED · sponsor: **Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins** · enrollment: 132 (actual)

## Conditions studied

- HPV16 Positive
- Cervical Intraepithelial Neoplasia (CIN 2/3)

## Interventions

- **BIOLOGICAL:** DNA vaccination
- **DEVICE:** Gene gun vaccine
- **BIOLOGICAL:** intramuscular vaccination
- **BIOLOGICAL:** intra-lesional vaccine administration
- **PROCEDURE:** therapeutic resection of the lesion
- **DRUG:** imiquimod

## Key facts

- **NCT ID:** NCT00988559
- **Lead sponsor:** Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-09
- **Primary completion:** 2016-07
- **Final completion:** 2016-07
- **Target enrollment:** 132 (ACTUAL)
- **Last updated:** 2018-07-09

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00988559

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00988559, "Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT00988559. Licensed CC0.

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