# Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

> **NCT00988715** · PHASE1 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 17 (actual)

## Conditions studied

- Chronic Myelomonocytic Leukemia
- Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
- Previously Treated Myelodysplastic Syndrome
- Recurrent Adult Acute Lymphoblastic Leukemia
- Recurrent Adult Acute Myeloid Leukemia
- Refractory Anemia With Excess Blasts
- Refractory Cytopenia With Multilineage Dysplasia
- Refractory Cytopenia With Multilineage Dysplasia and Ringed Sideroblasts
- Secondary Acute Myeloid Leukemia

## Interventions

- **BIOLOGICAL:** Pretargeted Radioimmunotherapy
- **DRUG:** Cyclosporine
- **DRUG:** Mycophenolate Mofetil
- **RADIATION:** Total-Body Irradiation
- **PROCEDURE:** Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Pharmacological Study
- **OTHER:** Laboratory Biomarker Analysis

## Key facts

- **NCT ID:** NCT00988715
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-04-21
- **Primary completion:** 2015-01
- **Final completion:** —
- **Target enrollment:** 17 (ACTUAL)
- **Last updated:** 2017-08-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00988715

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00988715, "Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT00988715. Licensed CC0.

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