# A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy

> **NCT00999167** · PHASE2 · COMPLETED · sponsor: **Amgen** · enrollment: 189 (actual)

## Conditions studied

- Cirrhosis
- Hepatic Encephalopathy

## Interventions

- **DRUG:** HPN-100
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT00999167
- **Lead sponsor:** Amgen
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-12
- **Primary completion:** 2012-04
- **Final completion:** 2012-04
- **Target enrollment:** 189 (ACTUAL)
- **Last updated:** 2024-07-10


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT00999167

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT00999167, "A Study of Safety and Efficacy of HPN-100 in Subjects With Cirrhosis and Episodic Hepatic Encephalopathy". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT00999167. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*