# A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction

> **NCT01114308** · PHASE3 · COMPLETED · sponsor: **Titan Pharmaceuticals** · enrollment: 287 (actual)

## Conditions studied

- Opioid Dependency

## Interventions

- **DRUG:** Probuphine (buprenorphine implant)
- **DRUG:** placebo implant
- **DRUG:** Buprenorphine

## Key facts

- **NCT ID:** NCT01114308
- **Lead sponsor:** Titan Pharmaceuticals
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-04
- **Primary completion:** 2011-05
- **Final completion:** 2011-05
- **Target enrollment:** 287 (ACTUAL)
- **Last updated:** 2018-12-31

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01114308

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01114308, "A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction". Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/clinical/NCT01114308. Licensed CC0.

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