# RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma

> **NCT01119599** · PHASE1 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 22 (actual)

## Conditions studied

- Acoustic Schwannoma
- Adult Anaplastic (Malignant) Meningioma
- Adult Anaplastic Astrocytoma
- Adult Anaplastic Ependymoma
- Adult Brain Stem Glioma
- Adult Choroid Plexus Neoplasm
- Adult Craniopharyngioma
- Adult Diffuse Astrocytoma
- Adult Ependymoblastoma
- Adult Ependymoma
- Adult Giant Cell Glioblastoma
- Adult Glioblastoma
- Adult Gliosarcoma
- Adult Grade I Meningioma
- Adult Grade II Meningioma
- Adult Medulloblastoma
- Adult Mixed Glioma
- Adult Myxopapillary Ependymoma
- Adult Oligodendroglioma
- Adult Papillary Meningioma
- Adult Pilocytic Astrocytoma
- Adult Pineal Gland Astrocytoma
- Adult Pineoblastoma
- Adult Pineocytoma
- Adult Primary Melanocytic Lesion of Meninges
- Adult Subependymal Giant Cell Astrocytoma
- Adult Subependymoma
- Adult Supratentorial Primitive Neuroectodermal Tumor
- Malignant Adult Intracranial Hemangiopericytoma

## Interventions

- **RADIATION:** 3-Dimensional Conformal Radiation Therapy
- **DRUG:** Gamma-Secretase Inhibitor RO4929097
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study
- **DRUG:** Temozolomide
- **PROCEDURE:** Therapeutic Conventional Surgery

## Key facts

- **NCT ID:** NCT01119599
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-05
- **Primary completion:** 2013-06
- **Final completion:** —
- **Target enrollment:** 22 (ACTUAL)
- **Last updated:** 2015-09-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01119599

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01119599, "RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT01119599. Licensed CC0.

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