A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas
Conditions
- Adult Anaplastic Astrocytoma
- Recurrent Grade III Glioma
- Recurrent Grade IV Glioma
- Adult Anaplastic Oligodendroglioma
- Adult Brain Tumor
- Adult Giant Cell Glioblastoma
- Adult Glioblastoma
- Adult Gliosarcoma
- Adult Mixed Glioma
- Recurrent Adult Brain Tumor
- Adult Anaplastic Oligoastrocytoma
- Recurrent High Grade Glioma
Interventions
- DRUG: flucytosine
- OTHER: polymerase chain reaction
- OTHER: immunohistochemistry staining method
- BIOLOGICAL: gene therapy
- OTHER: pharmacological study
- OTHER: 3-Tesla magnetic resonance imaging
- OTHER: laboratory biomarker analysis
- PROCEDURE: therapeutic conventional surgery
- BIOLOGICAL: E. coli CD-expressing genetically modified neural stem cells
Sponsor
City of Hope Medical Center