# Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies

> **NCT01175785** · PHASE2 · COMPLETED · sponsor: **Nohla Therapeutics, Inc.** · enrollment: 15 (actual)

## Conditions studied

- Accelerated Phase Chronic Myelogenous Leukemia
- Adult Acute Myeloid Leukemia in Remission
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Adult Acute Myeloid Leukemia With Del(5q)
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- Childhood Acute Lymphoblastic Leukemia in Remission
- Childhood Acute Myeloid Leukemia in Remission
- Childhood Chronic Myelogenous Leukemia
- Childhood Myelodysplastic Syndromes
- Chronic Phase Chronic Myelogenous Leukemia
- de Novo Myelodysplastic Syndromes
- Previously Treated Myelodysplastic Syndromes
- Refractory Anemia
- Refractory Anemia With Excess Blasts
- Refractory Anemia With Excess Blasts in Transformation
- Relapsing Chronic Myelogenous Leukemia
- Secondary Myelodysplastic Syndromes

## Interventions

- **PROCEDURE:** umbilical cord blood transplantation
- **DRUG:** fludarabine phosphate
- **DRUG:** cyclophosphamide
- **BIOLOGICAL:** ex vivo-expanded cord blood progenitor cell infusion
- **RADIATION:** total-body irradiation
- **DRUG:** cyclosporine
- **DRUG:** mycophenolate mofetil
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT01175785
- **Lead sponsor:** Nohla Therapeutics, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-08
- **Primary completion:** 2014-08
- **Final completion:** 2014-08
- **Target enrollment:** 15 (ACTUAL)
- **Last updated:** 2019-03-05

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01175785

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01175785, "Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01175785. Licensed CC0.

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