# Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

> **NCT01190930** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 9350 (actual)

## Conditions studied

- Acute Lymphoblastic Leukemia
- Adult B Lymphoblastic Lymphoma
- Ann Arbor Stage I B Lymphoblastic Lymphoma
- Ann Arbor Stage II B Lymphoblastic Lymphoma
- Childhood B Acute Lymphoblastic Leukemia
- Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
- Childhood B Lymphoblastic Lymphoma
- Down Syndrome
- Hypodiploid B Acute Lymphoblastic Leukemia
- Philadelphia Chromosome Positive

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin Hydrochloride
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Leucovorin Calcium
- **DRUG:** Mercaptopurine
- **DRUG:** Methotrexate
- **DRUG:** Pegaspargase
- **OTHER:** Quality-of-Life Assessment
- **OTHER:** Questionnaire Administration
- **DRUG:** Thioguanine
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT01190930
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2010-08-09
- **Primary completion:** 2019-03-31
- **Final completion:** 2026-03-31
- **Target enrollment:** 9350 (ACTUAL)
- **Last updated:** 2026-03-31

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01190930

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01190930, "Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT01190930. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*