# Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas

> **NCT01193842** · PHASE1,PHASE2 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 107 (actual)

## Conditions studied

- AIDS-Related Plasmablastic Lymphoma
- AIDS-Related Primary Effusion Lymphoma
- Ann Arbor Stage I Diffuse Large B-Cell Lymphoma
- Ann Arbor Stage I Grade 3 Follicular Lymphoma
- Ann Arbor Stage II Diffuse Large B-Cell Lymphoma
- Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma
- Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma
- Ann Arbor Stage III Diffuse Large B-Cell Lymphoma
- Ann Arbor Stage III Grade 3 Follicular Lymphoma
- Ann Arbor Stage IV Diffuse Large B-Cell Lymphoma
- Ann Arbor Stage IV Grade 3 Follicular Lymphoma
- HIV Infection
- Plasmablastic Lymphoma
- Primary Effusion Lymphoma
- Recurrent Diffuse Large B-Cell Lymphoma
- Recurrent Grade 3 Follicular Lymphoma

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Doxorubicin Hydrochloride
- **DRUG:** Etoposide
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study
- **DRUG:** Prednisone
- **BIOLOGICAL:** Rituximab
- **DRUG:** Vincristine Sulfate
- **DRUG:** Vorinostat

## Key facts

- **NCT ID:** NCT01193842
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-10-06
- **Primary completion:** 2016-11-12
- **Final completion:** 2022-05-19
- **Target enrollment:** 107 (ACTUAL)
- **Last updated:** 2023-11-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01193842

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01193842, "Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01193842. Licensed CC0.

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